Chronic cystitis (inflammation of the bladder) and especially interstitial cystitis (IC) are rare, but serious and, in some cases, highly burdensome diseases. For many patients, IC means a life of discomfort, such as frequent urination during the day and night, constant urinary urge that is unable to be suppressed in some cases, burning sensation and pain, e.g. involving the bladder, lower abdomen, urethra, and genitals.
Damage to the protective lining of the bladder is commonly the cause
Chronic cystitis is most commonly caused by damage to the protective lining of the bladder (GAG layer). Here, the wall of the bladder is increasingly exposed to damaging substances contained in the urine, such as potassium, triggering a continuous inflammatory process. These symptoms can have a negative impact on every aspect of life, depending on how pronounced they are. As a result, besides purely symptomatic treatment with pain medication or drugs that suppress the urinary urge, a lasting solution, i.e. a therapy that comes close to addressing the underlying cause and protects and restores the bladder wall, is essential.
Instillation therapies are the most promising treatment options
Current therapies are able to prevent the progression of the disease and alleviate symptoms. These include pain management and bladder irrigation (instillation therapy) with medications to restore the damaged protective lining of the bladder. Solutions for instillation therapy, such as Instillamed®, are currently considered to be the most promising treatment options.